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Regulation of HEMATOPOIESIS AT THE SINGLE CELL LEVEL 

Every second, millions of blood cells are made in our bone marrow. 

How is this process regulated to adapt to varying cell demands during injury? How is it quality controlled to avoid dysplasia and cancer?

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Epigenetic Evolution

of Cancer Cell

CLONES

Beyond genetic mutations, cancer cells are also constantly experiencing changes in their gene expression patterns.

We aim to uncover which variation helps the cancer adapt during metastasis and therapy, with the goal to create new cancer drugs.

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CELLULAR MEMORY

OF REGENERATION

Stem cells record past experiences in their chromatin, and these information can be inherited by their offspring.

 

We study functional differences across families of cells in regenerative tissues to better understand human disease and aging. 

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ADVANCED METHODS

FOR SINGLE CELL

LINEAGE TRACING

The major technological leap that enable our  research are Single Cell Sequencing and Lineage Tracing.

Combined, these methods allow us to read the life stories of thousands of individual cells and their ancestries inside the body. 

OUR PUBLICATIONS