Quantitative Stem cell
Group leader: Alejo E. Rodriguez-Fraticelli, PhD
Regulation of Hematopoietic
Epigenetic Evolution of Cancer Cells
Cellular Memory of
Advanced methods for lineage tracing
Every second, millions of blood cells are made in our bone marrow.
How is this process regulated to adapt to varying cell demands during injury? How is it quality controlled to avoid dysplasia and cancer?
Beyond just mutations, cancer cells are also constantly experiencing changes in their gene expression. We aim to find which variation helps the cancer adapt during metastasis and therapy, to create new cancer drugs.
Stem cells record past experiences in their chromatin, and these changes are inherited by their offspring. We study functional differences across families of cells in regenerative tissues to better understand human disease.
The major technological leaps that enable our research are Single Cell Sequencing and Lineage Tracing. Combined, these methods allow us to read the life stories of thousands of individual cells and their ancestries inside the body.